Comayagua is a town in Honduras, some 80 km northwest of Tegucigalpa on the highway to San Pedro Sula at 14.46°N, 87.65°W at an elevation of 594 meters above sea level. In 2003 the estimated population was 74,000 people. It is the capital of Honduras's Comayagua department.

Anyone driving from San andres and providencia to Tegucigalpa should get out of the bus or car here and go and see the former capital of Honduras. Founded in 1537 it was the capital of Honduras for more than 300 years but was heavily damaged by fire during a civil war in 1873. Cobnsequently the capital was moved to Tegucigalpa.

Comayagua was founded with the name Santa María de la Nueva Valladolid by Conquistador Alonso de Cáceres under orders from Francisco de Montejo, Governor of Yucatán on December 8, 1537. From 1540 on Comayagua was the capital of the Honduras district of New Spain. After independence from Spain it was the capital of the state of Honduras in the United States of Central America. After Honduras became an independent republic, the capital alternated between Comayagua and Tegucigalpa (Comayagua being preferred by Conservative administrations, and Tegucigalpa by Liberal ones) before being permanently established at Tegucigalpa in 1880.

The town is noted for its wealth of Spanish Colonial architecture. However, the city is dusty and not highly developed. There are several buses daily to Tegucigalpa. The central square has a cathedral with the oldest clock in the Americas. The national School of Fine Arts is located in Comayagüela (not in Comayagua), a neighborhood of Tegucigalpa.